Gene therapy for lung cancer

Lung cancer gene therapy

Abbreviations: small cell lung cancer (SCLC); non-small cell lung cancer (NSCLC); intratumoral injection of Ad-p53 (INGN 201); murine double minute-2 (MDM2); cisplatin (CDDP); active metabolite of irinotecan (CPT-11); O(6)-methylguanine-DNA methyltransferase (MGMT); retinoblastoma (RB); fragile histidine triad (FHIT); tumor necrosis factor-related apoptosis-inducing ligand (TRAIL); triplex form...

Gene therapy for lung cancer and mesothelioma.

Gene therapy in management of lung cancer

as the standard first-line therapy in patients with advanced NSCLC. However, resistance to platinum-based drugs reduces the survival rate which, as a result, has not improved to anything like the extent seen in other cancers [6]. Advances in the understanding of molecular genetics in NSCLC have led to the identification of key genetic aberrations in NSCLC. These genetic aberrations occur in onc...

gene expression profiling for cancer targeted therapy

background : lung cancer is still the leading cause of cancer- related deaths and most of themâ  are normally diagnosed in late stages, so there is an urgent need to establish reliable tools for the identification at early stages of the disease. in this study, we use an eleven gene signature test to examine lung biopsy specimens for diagnostic, prognostic & therapeutic purposes. methods : bronc...

Nanoparticle-based targeted gene therapy for lung cancer.

Despite striking insights on lung cancer progression, and cutting-edge therapeutic approaches the survival of patients with lung cancer, remains poor. In recent years, targeted gene therapy with nanoparticles is one of the most rapidly evolving and extensive areas of research for lung cancer. The major goal of targeted gene therapy is to bring forward a safe and efficient treatment to cancer pa...